Research

The Shendure Lab is part of the Howard Hughes Medical Institute (opens in new tab), Brotman Baty Institute for Precision Medicine (opens in new tab), Seattle Hub for Synthetic Biology (opens in new tab) and the Department of Genome Sciences (opens in new tab) at the University of Washington (opens in new tab) (Seattle, WA). The mission of our lab is to develop and apply new technologies and methods at the intersection of genomics, molecular biology and developmental biology. Our research group pioneered exome sequencing and its earliest applications to gene discovery for Mendelian disorders and autism; cell-free DNA diagnostics for cancer and reproductive medicine; massively parallel reporter assays, saturation genome editing; combinatorial single cell molecular technologies; and genome editing based molecular recording technologies. Our ongoing work generally falls into the following areas, which are listed below as links to representative publications in each area.

• Developing New Molecular Methods
• Genomic Approaches to Developmental Biology
• Massively Parallel Functional Genomics
• Translating Genomics to the Clinic
• Genetic Basis of Human Disease
• Genome Sequencing Technologies